Blood—Brain Barrier to Ammonia in Humans
نویسندگان
چکیده
منابع مشابه
The gut does not contribute to systemic ammonia release in humans without portosystemic shunting.
The gut is classically seen as the main source of circulating ammonia. However, the contribution of the intestines to systemic ammonia production may be limited by hepatic extraction of portal-derived ammonia. Recent data suggest that the kidney may be more important than the gut for systemic ammonia production. The aim of this study was to quantify the role of the kidney, intestines, and liver...
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Nitrogen oxide (NO) conversion to ammonia (NH3) over iron oxide clusters is investigated using density functional theory calculations. The introduction of NO and H2 over gas-phase Fe4O2 results in the formation of NH3 and H2O without activation barriers. The key reaction is barrier free conversion of NO to N and H2O where the physical origin rests on negative-negative repulsion of NO over iron ...
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Ammonium salts have been shown to have significantly different toxicities (LD,0's) when administered intravenously under controlled conditions (1). This differential toxicity appeared to be related to the change in blood pH induced by each salt. The normal blood pH (7.4) is close enough to the pKbh of ammonia,2 approximately 8.90 at 370 C. (2), so that any change in blood pH would significantly...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1984
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1984.76